Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure
Recruiting now NCT07369856
Run by Cardiology Research UBC · for 18 and older · All sexes
What this study is about
Heart failure is a chronic condition that causes congestion and frequent hospitalizations. Diuretic doses are usually adjusted based on clinical judgment without an objective measure of response. This study will test the feasibility of using point-of-care urine sodium measurements to guide up-titration or down-titration of loop diuretics in ambulatory patients with heart failure. Participants will be assigned to one of three groups based on congestion status. Groups 1 and 2 will be randomized 1:1 to natriuresis-guided therapy or standard care. Group 3 will be observational. The 90-day pilot trial will evaluate feasibility, clinical outcomes, and usability of a urine sodium-guided titration strategy.
Who can join (things the study team will check)
✅ You may be able to join if…
- Age ≥18 years
- Diagnosis of heart failure according to the Universal Definition
- Use of loop diuretics
- Residing in VCH or PHC regions Group-specific inclusion: Group 1: Congestion score ≥5 OR objective congestion; stable furosemide ≥1 week Group 2: NYHA I-II; congestion score <5; no recent HF hospitalization; stable furosemide ≥1 month Group 3: First 100 eligible patients not meeting criteria for Groups 1 or 2
🚫 You may not be able to join if…
- eGFR <20 mL/min/1.73m²
- Renal replacement therapy
- High-risk clinical status requiring hospitalization
- Inability to consent or perform required urine sampling
Where this trial is running
- Vancouver General Hospital, Vancouver, British Columbia, Canada
Who to contact
Natalie Bloch, MD · 604-875-4111 · natalie.blochisenberg@vch.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07369856.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.