Ultrasound Liver Imaging for Classification of Metabolic Dysfunction-associated Steatotic Liver Disease

What this study is about

Tissue elasticity and viscosity correlate with pathology. These tissue properties are typically evaluated subjectively using palpation. The purpose of "elastography" is to provide an objective elasticity image that is equivalent to the remote palpation of tissue. The investigators have developed elastography imaging systems based on ultrasound and magnetic resonance imaging and have applied them previously to prostate imaging, breast imaging in patients and liver imaging in healthy volunteers. A first objective of this study is to compare the investigators' ultrasound shear wave absolute vibro-elastography (S-WAVE) technology with the existing clinical standard, FibroScan, and magnetic resonance elastography to quantify liver stiffness in healthy volunteers and in patients suspected of fatty liver disease. A second objective of this study is to compare ultrasound-based liver tissue fat measurement with MRI-based measurements. A third objective of this study is to determine whether ultrasound can be used to assess liver inflammation.

Who can join (things the study team will check)

✅ You may be able to join if…

• Participants between the ages of 19 and 75.
• healthy volunteers and have no known history of liver disease
• patients with chronic liver disease, with fibrosis stages F0, F1, F2, F3 or F4.

🚫 You may not be able to join if…

• Retained wires from an electronic implant that has been removed (i.e. pacemaker wires not attached to a pacemaker)
• Cardiac pacemaker or defibrillator
• Metal in eye or orbit
• Ferromagnetic aneurysm clip
• Pregnancy
• Makeup tattoos that are not designed to fade over time
• Stainless steel intrauterine device (IUD) Depending on the individual situation, patients MAY NOT be able to participate the MRI exam if they have/had any of the following:
• Artificial heart valve
• Ear or eye implant
• Brain aneurysm clip
• Implanted electronic device (i.e. drug infusion pump, electrical stimulator)
• Coil, catheter, or filter in any blood vessel
• Orthopedic hardware (artificial joint, plate, screw, rod)
• Shrapnel, bullets, or other metal fragments
• Surgery, medical procedure or tattoos (including tattooed eyeliner) in the last six weeks
• Other metallic prostheses

Where this trial is running

• University of British Columbia, Vancouver, British Columbia, Canada

Who to contact

Septimiu Salcudean, PhD · 1(604)822-3243 · tims@ece.ubc.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07373769.