A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

What this study is about

This is a randomised, multicentre, controlled, open-label, Phase III global study comparing the efficacy and safety of AZD0120 versus standard regimens (DKd \[daratumumab, carfilzomib, and dexamethasone\], DPd \[daratumumab, pomalidomide, and dexamethasone\], PVd \[pomalidomide, bortezomib and dexamethasone\], or Kd \[carfilzomib and dexamethasone\]) in participants with RRMM.

Who can join (things the study team will check)

✅ You may be able to join if…

• Age ≥ 18 years
• Documented diagnosis of multiple myeloma according to the IMWG diagnostic criteria
• Documented evidence of measurable disease:
  • Serum M-protein level ≥ 1 g/dL
  • Urine M-protein level ≥ 200 mg/24h
  • Serum immunoglobulin free light chain ≥ 10 mg/dL (100 mg/L) and abnormal serum immunoglobulin kappa lambda free light chain ratio
• Documented evidence of PD by IMWG 2016 criteria based on investigator's determination during or after the most recent line of therapy. Participants with only 1 prior line of therapy must have progressed within 47 months of a stem cell transplant, or if not transplanted, then within 42 months of starting initial therapy
• Received 1 to 3 lines of prior therapy including an IMiD and either a PI or a CD38 antibody. Participant must have undergone at least 2 complete cycles of treatment for each line of therapy, unless PD was the best response to the line of therapy
• Eligible to receive at least one of the standard regimens (DKd, PVd, DPd, or Kd) as determined by the Investigator.
• ECOG performance status score of 0 to 1
• Adequate hematology and chemistry laboratory values:
  • Haemoglobin ≥ 8.0 g/dL
  • Absolute neutrophil count ≥ 1 × 10\^9/L (1000 per mm3)
  • Platelet count ≥ 75 × 10\^9/L (75000 per mm3) in participants with < 50% of bone marrow nucleated cells are plasma cells or ≥ 50 × 10\^9/L (50000 per mm3) in participants with ≥ 50% of bone marrow nucleated cells are plasma cells
  • Absolute lymphocyte count ≥ 300/µL (0.3 × 109/L)
  • Total bilirubin ≤ 1.5 × ULN in the absence of Gilbert's syndrome or ≤ 3 × ULN if the participant has Gilbert's syndrome. AST and ALT≤ 3.0 × ULN. CrCl by Cockcroft and Gault method ≥ 30 mL/minute

🚫 You may not be able to join if…

• Known active, or prior history of CNS involvement or exhibits clinical signs of meningeal involvement of MM.
• Primary amyloidosis, active plasma cell leukaemia, Waldenstrom macroglobulinemia or Polyneuropathy Organomegaly Endocrinopathy M-protein and Skin (POEMS) syndrome.
• Participants with primary refractory MM (failed to generate at least a minimal response to any prior therapy)
• Significant neurological or psychiatric condition
• Significant medical condition that places the participant at an unacceptable risk for treatment-related complications
• Previously received any prior BCMA-targeted treatment
• Previously received CAR-T or CAR-NK therapy directed at any target
• Previously received T-cell engager therapy directed at any target
• Previously received allogeneic stem cell transplantation at any time during prior therapy or received autologous stem cell transplantation within 12 weeks of randomization

Where this trial is running

• Research Site, Gilbert, Arizona, United States
• Research Site, Phoenix, Arizona, United States
• Research Site, Tucson, Arizona, United States
• Research Site, La Jolla, California, United States
• Research Site, Sacramento, California, United States
• Research Site, Santa Monica, California, United States
• Research Site, Denver, Colorado, United States
• Research Site, New Haven, Connecticut, United States
• Research Site, Washington D.C., District of Columbia, United States
• Research Site, Coral Gables, Florida, United States
• Research Site, Tampa, Florida, United States
• Research Site, Atlanta, Georgia, United States

+ 126 more sites.

Who to contact

AstraZeneca Clinical Study Information Center · 1-877-240-9479 · information.center@astrazeneca.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07391657.