A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

What this study is about

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Who can join (things the study team will check)

✅ You may be able to join if…

• adults aged 18 years or older with
• obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with
• overweight (BMI of 27.0 kg/m2 to <30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.

Where this trial is running

• Arizona Clinical Trials-Chandler, Chandler, Arizona, United States
• Clinical Research Institute of Arizona, Sun City West, Arizona, United States
• Arizona Clinical Trials (ACT) - Tucson, Tucson, Arizona, United States
• San Fernando Valley Health Institute, Canoga Park, California, United States
• Ark Clinical Research, Fountain Valley, California, United States
• Paragon Rx Clinical, Garden Grove, California, United States
• Torrance Clinical Research Institute, Inc., Lomita, California, United States
• Ark Clinical Research, Long Beach, California, United States
• Collaborative Neuroscience Research, LLC, Los Alamitos, California, United States
• Paradigm Clinical Research-Modesto, Modesto, California, United States
• Paradigm Clinical Research Centers, LLC, San Diego, California, United States
• University Clinical Investigators, Incorporated, Tustin, California, United States

+ 53 more sites.

Who to contact

Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07575932.