A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
Recruiting now Phase 2 NCT07589608
Run by Eli Lilly and Company · for 18 to 75 · All sexes
What this study is about
The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.
Who can join (things the study team will check)
✅ You may be able to join if…
- See Master Protocol CWMM (NCT06143956) for inclusion criteria
🚫 You may not be able to join if…
- Have type 1 diabetes or type 2 diabetes
- Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
- Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
- Have a history of acute or chronic pancreatitis
- All concomitant medications should be at a stable dose for at least 3 months prior to screening
Where this trial is running
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa, Chandler, Arizona, United States
- Headlands Research - Scottsdale, Scottsdale, Arizona, United States
- The Institute for Liver Health II dba Arizona Liver Health-Tucson, Tucson, Arizona, United States
- NorCal Medical Research, Inc, Greenbrae, California, United States
- Velocity Clinical Research, Huntington Park, Huntington Park, California, United States
- Peninsula Research Associates, Rolling Hills Estates, California, United States
- Diablo Clinical Research, Inc., Walnut Creek, California, United States
- Stamford Therapeutics Consortium, Stamford, Connecticut, United States
- New Horizon Research Center, Miami, Florida, United States
- Indago Research & Health Center, Inc, Miami Lakes, Florida, United States
- Suncoast Clinical Research, Inc., New Port Richey, Florida, United States
- Charter Research - Winter Park, Orlando, Florida, United States
+ 28 more sites.
Who to contact
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 317-615-4559 · LillyTrials@Lilly.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07589608.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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