A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity
Recruiting now Phase 3 NCT07595549
Run by Pfizer · for 18 and older · All sexes
What this study is about
The purpose of this clinical study is to learn about the effects and safety of berobenatide (PF-08653944). This may help people with overweight or obesity lose weight. People in this study may also have type 2 diabetes. About 950 adults will be in this study. Berobenatide will be compared to a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. Berobenatide or placebo is given by a shot under the skin in the belly area. The objective of the study is to compare the experiences of people receiving berobenatide to those of the people who do not to assess if the study medicine is effective and safe. People will take part in this study for about 20 months. During this time, they will have about 15 study visits at the site. They will also have 2 study visits over the phone.
Who can join (things the study team will check)
✅ You may be able to join if…
- Aged ≥18 years.
- BMI of: ≥30 kg/m2 or ≥27.0 kg/m2 to <30.0 kg/m2 and must have at least 1 of the following weight-related co-morbidities: hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2D.
🚫 You may not be able to join if…
- Have a self-reported body weight change greater than 5% within 90 days prior to Screening.
- Diagnosis of type 1 diabetes or any other form of diabetes other than T2D.
- History of acute or chronic pancreatitis.
- Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).
Where this trial is running
- San Fernando Valley Health Institute, Canoga Park, California, United States
- Headlands Research California, LLC, Escondido, California, United States
- ImmuniMet, LLC, Modesto, California, United States
- Clinical Trials Research, Sacramento, California, United States
- University Clinical Investigators, Inc., Tustin, California, United States
- Diablo Clinical Research, Inc., Walnut Creek, California, United States
- Southern California Retina Specialists, West Hills, California, United States
- Nature Coast Clinical Research, Crystal River, Florida, United States
- West Coast Eye Institute, Lecanto, Florida, United States
- South Broward Research, Miramar, Florida, United States
- Suncoast Clinical Research, Inc., New Port Richey, Florida, United States
- West Coast Medical Associates, New Port Richey, Florida, United States
+ 38 more sites.
Who to contact
Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07595549.
Verify everything on the official ClinicalTrials.gov record. Page updated September 2026.