A Study to Assess the Safety, Tolerability and Efficacy of ION775
Recruiting now Phase 2 NCT07604974
Run by Ionis Pharmaceuticals, Inc. · for 18 and older · All sexes
What this study is about
The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).
Who can join (things the study team will check)
✅ You may be able to join if…
- Adult males and females with HTG (fasting TG more than or equal to (≥) 350 milligrams per deciliter (mg/dL) [3.95 millimoles per liter (mmol/L)] or with sHTG (fasting TG ≥ 500 mg/dL [5.65 mmol/L]).
- Participants should be on standard of care lipid-lowering medications per local guidelines.
🚫 You may not be able to join if…
- Hemoglobin A1c (HbA1c) ≥ 8.5% at Screening.
- Alanine aminotransferase or aspartate aminotransferase > 2.0 × upper limit of normal.
- Total bilirubin > 1.5 upper limit of normal unless due to Gilbert's syndrome.
- Estimated GFR < 30 mL/min/1.73 m\^2. Note: Other protocol pre-specified inclusion/exclusion criteria may apply.
Where this trial is running
- Ionis Investigative Site, Lincoln, California, United States
- Ionis Investigative Site, Aurora, Colorado, United States
- Ionis Investigative Site, Boca Raton, Florida, United States
- Ionis Investigative Site, Miami, Florida, United States
- Ionis Investigative Site, Miramar, Florida, United States
- Ionis Investigative Site, Columbus, Georgia, United States
- Ionis Investigative Site, Louisville, Kentucky, United States
- Ionis Investigative Site, Flint, Michigan, United States
- Ionis Investigative Site, Munroe Falls, Ohio, United States
- Ionis Investigative Site, Little River, South Carolina, United States
- Ionis Investigative Site, Houston, Texas, United States
- Ionis Investigative Site, Lampasas, Texas, United States
+ 4 more sites.
Who to contact
Ionis Pharmaceuticals, Inc. · 1-844-828-3770 · IonisION775-CS2@clinicaltrialmedia.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07604974.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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