A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

Opening soon Phase 2 NCT07772531

Run by Bristol-Myers Squibb · for 18 to 65 · All sexes

What this study is about

A Study to Evaluate BMS-986511 in Adults with Major Depressive Disorder

Who can join (things the study team will check)

✅ You may be able to join if…

Participants must meet the MDD diagnosis per DSM-5 criteria confirmed by structured interview.
Participant must have current moderate to severe MDE confirmed by clinical assessment and validated scale.
Participant must have current MDE duration >12 weeks at screening.
Outpatient participants able to comply with study procedures.
Participant require medication washout completed before baseline.
Participant must have BMI within protocol range.
Participants must meet reproductive safety requirements.

🚫 You may not be able to join if…

Participants must not have other primary psychiatric disorders or a history of treatment-resistant depression during the current episode.
Participants must not have recent history of active suicidal ideation or attempt within the past year.
Participants must not have prior lifetime treatment with electroconvulsive therapy, ketamine/esketamine, deep brain stimulation, or transcranial magnetic stimulation.
Participants must not have recent history of alcohol/substance abuse or use of cannabis.
Participants must not have significant ECG abnormalities, or poorly controlled diabetes.
Other protocol defined inclusion/exclusion criteria apply.

Where this trial is running

Local Institution - 0144, Phoenix, Arizona, United States
Local Institution - 0038, Little Rock, Arkansas, United States
Local Institution - 0047, Rogers, Arkansas, United States
Local Institution - 0046, Garden Grove, California, United States
Local Institution - 0042, Glendale, California, United States
Local Institution - 0071, Lemon Grove, California, United States
Local Institution - 0079, Oakland, California, United States
Local Institution - 0050, Upland, California, United States
Local Institution - 0007, Jacksonville, Florida, United States
Local Institution - 0024, Orlando, Florida, United States
Local Institution - 0140, Atlanta, Georgia, United States
Local Institution - 0044, Gaithersburg, Maryland, United States

+ 15 more sites.

Who to contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com · 855-907-3286 · Clinical.Trials@bms.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07772531.

Open the interactive checklist for this trial →

Verify everything on the official ClinicalTrials.gov record. Page updated September 2026.

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