Smoking clinical trials recruiting in Canada

Accelerated dTMS Smoking Cessation

Recruiting nowPhase 22 sites

The goal of this clinical trial is to examine whether a 5-day course of bilateral accelerated deep transcranial magnetic stimulation (aTMS) is a feasible treatment to help adults (18-65) with Tobacco Use Disorder to quit smoking. This study…

Smoking Cessation and Menstrual Cycle Phase

Recruiting nowPhase 41 site

Tobacco use is a risk factor for at least 20 types of cancer and remains the leading preventable cause of cancer in Canada. Smoking cessation is an important cancer prevention strategy for the close to 2 million Canadian women who currently…

Implementation of Transcranial Magnetic Stimulation for Smoking Cessation

Recruiting nowPhase 41 site

Repetitive transcranial magnetic stimulation (rTMS) is an alternative non-invasive treatment to help people quit smoking. rTMS uses a magnetic field to stimulate regions of the brain that are involved in addiction. The two brain regions tha…

tDCS Plus Varenicline for Smoking Cessation

Recruiting nowPhase 41 site

The goal of this clinical trial is to determine if active transcranial direct current stimulation (tDCS) plus varenicline is an effective, safe and accessible treatment option for smoking cessation. The main questions this trial aims to ans…

Semaglutide for Smoking Cessation in Patients With Diabetes

Recruiting nowPhase 31 site

To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of semaglutide as an adjunct to combination NRT in supporting smoking cessation for patients with diabetes.

Smoking Cessation Intervention Including Health Navigators to Address Unmet Social Needs of Parents Who Smoke

Opening soon2 sites

Background: The goal of this study is to address parental smoking and social adversity, which can present an obstacle for smoking cessation, in order to decrease childhood exposure to second-hand cigarette smoke. To address these factors, t…

Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial

Recruiting nowPhase 41 site

Tobacco smoking is the leading preventable cause of morbidity and mortality worldwide. However, currently available treatments, including standard pharmacotherapy and behavioural support, are limited in their efficacy, tolerability, and acc…

Aggressive Smoking Cessation Trial (ASAP)

Recruiting nowPhase 313 sites

The ASAP Trial is a 5-year, multi-centre, randomized controlled trial that will assess the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk. It will recruit 798 adult pa…

The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments

Recruiting now4 sites

The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory c…

Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation

Recruiting nowPhase 41 site

The purpose of this vanguard trial is to test whether clients of Sun Life are willing to join in a quit smoking program that offers counselling and tobacco cessation products to all participants over a 12-month period. The study team will t…

Longitudinal Study of Xenon-129 MRI Imaging Effects of Cannabis Smoking

Recruiting now1 site

This is a longitudinal study of the long-term health impact of cannabis smoking on the lungs. Participants will be followed over a period of 3 years, and impacts of cannabis smoking on the lungs will be measured with magnetic resonance imag…

The Canadian Lung Outcomes in Users of Vaping Devices Study

Recruiting now8 sites

Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient and propose …

Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

Recruiting now1 site

This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonanc…

The Use of tDCS for Vaping Reduction

Recruiting now1 site

Project Summary - tDCS for Vaping Reduction Background: While the prevalence of tobacco smoking has plateaued over the last several years, the prevalence of nicotine vaping (e-cigarettes) continues to increase exponentially in Canada. Orig…

Vaping Adverse Lung and Heart Events Cohort

Recruiting now1 site

This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.

Common questions

How do I find a smoking clinical trial near me in Canada?

Use Beacon's free search: enter "smoking", your age, and your location, and you'll see recruiting trials sorted by distance, each explained in plain language — including sites just across the US border. Beacon searches the full official registry and never requires an account.

Does joining a clinical trial cost money?

The study treatment and study-related tests are usually provided at no cost, and some trials help with travel. In Canada, your provincial health coverage continues to apply to your routine care — always confirm details with the study team.

Can I leave a clinical trial after joining?

Yes. Participation is always voluntary, and you can leave a trial at any time, for any reason, without losing your normal medical care.

Do I qualify for these trials?

Every trial has its own eligibility criteria. Beacon translates each trial's criteria into a plain-language checklist you can review and bring to your doctor — only the study team can confirm whether you qualify.