Essais cliniques au Canada : douleur chronique

Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study

Recruiting now11 sites

Pain is one of the most common symptoms of extreme stress in youth. Without treatment, short-term pain can last for months to years (called 'chronic pain'; CP), a problem already affecting 1 in 5 Canadian youth. The COVID-19 pandemic is one…

Relieving Chronic Pain in Older Adults With Transcranial Direct Current Stimulation

Recruiting now3 sites

The primary objective of this study is to determine, in a healthcare setting, the effectiveness of actual tDCS in reducing pain compared with placebo tDCS. This is a multicenter randomized controlled trial with parallel groups (real tDCS vs…

Music as an Adjunct to Ketamine Therapy for Chronic Pain

Recruiting now1 site

Intravenous (IV) ketamine is a treatment option for patients with chronic pain that does not respond to standard therapies, primarily working by blocking NMDA receptors in the brain. Beyond pain relief, ketamine can produce dissociative sen…

Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty

Recruiting nowPhase 23 sites

Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthro…

Analgesia Nociception Index In Pediatric Patients With Chronic Pain

Opening soon1 site

The goal of this observational study is to learn about the analgesia nociceptive index (ANI) is associated with pain sensitivity in patients between the ages of 9-17 who are experiencing chronic pain. The main question it aims to answer is:…

Power Over Pain Portal: A Stepped-care Virtual Solution to Deliver Early Intervention to Canadian Youth With Chronic Pain

Recruiting now1 site

The COVID-19 pandemic is presenting one of the greatest threats to youth mental health seen in generations. Pain is one of the most common symptoms of extreme stress in youth. In 2020, the investigators created an online "stepped-care" prog…

Comparison of the Efficacy of an Empowered Relief Single-Session Versus Standard Care for Reducing Postoperative Pain Following Elective Orthopedic Surgery: A Randomized Controlled Trial

Recruiting now1 site

The purpose of this study is to evaluate the efficacy and acceptability of the French-Canadian version of ER compared to standard care in reducing postoperative pain and improving recovery outcomes at 6-week and 3-month follow-ups after ele…

Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment

Opening soon1 site

The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain. Participants meeting the criteria for chronic/persistent pain (confirmed via s…

Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN

Recruiting nowPhase 22 sites

This is a feasibility study to examine the use of use of Psilocybin (magic mushrooms) to alleviate pain in chronic neuropathic pain. While theoretical mechanisms demonstrate promise, there is no clinical evidence. This vacuum of clinical e…

RTMS and Steroid Joint Steroid Injection in Chronic Spinal Pain

Recruiting now2 sites

Chronic spinal pain (CSP) is one of the most common chronic pain conditions globally. Steroid joint injections (SJI) are a routine treatment option for patients with CLBP that is recalcitrant to other treatments. However, SJI has been shown…

Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients

Recruiting now1 site

Prospective observational crossover study of 150 consenting adult patients who are undergoing chronic pain management. For insomnia treatment, each patient ingests prescribed doses of Lemborexant or Zopiclone or Clonidine on alternate night…

Neuromodulation Parameter Efficacy

Recruiting now1 site

The objective of this study is to determine the efficacy of neuromodulation using various stimulation paradigms in the treatment of several disorders including chronic pain.

iCanCope With Post-Operative Pain (iCanCope PostOp)

Recruiting now2 sites

There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone app called "i…

Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial

Recruiting nowPhase 21 site

This is a Health Canada regulated internal pilot study designed to assess the feasibility, tolerability, and preliminary efficacy of 3, 4-methylenedioxymethamphetamine hydrochloride capsules-AT for chronic neuropathic pain to inform a large…

Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation

Recruiting now1 site

Spinal cord stimulation (SCS) relies on stimulation of pain-relieving pathways in the spinal cord to treat chronic neuropathic pain. Traditional paresthesia-based SCS (PB-SCS) relies on providing analgesia through stimulation of spinal cord…

Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

Recruiting nowPhase 317 sites

Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast …

Combining Brain Stimulation and Physiotherapy for the Management of Chronic Low Back Pain

Recruiting now2 sites

Chronic low back pain (CLBP) is a major health challenge in Canada, leading to substantial disability and socioeconomic burden, particularly among Veterans. In military Veterans, LBP is the most common chronic pain condition. Conventional i…

A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children

Recruiting now16 sites

The purpose of this study is to investigate the prevalence, risk factors and consequences of chronic post-surgical pain in children aged 0-16 years through a number of questionnaires completed at various timepoints, from before surgery up t…

Self-hypnosis Training for Chronic Pain Management

Recruiting now1 site

Title: Self-hypnosis training in chronic pain management: A pilot study Our primary objective concerns the effect of hypnosis intervention on change in 24h pain between T0 (pre-intervention) and T4 (3-month follow-up). The secondary objecti…

Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication

Recruiting nowPhase 21 site

This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients receiving …

The METRIC Study Protocol

Recruiting now1 site

The goal of this clinical trial is to test the effects of spinal manipulative therapy in individuals with chronic primary low back pain and determine the neurophysiological mechanisms underlying pain relief. The main questions it aims to an…

Brain, Psychological and Epigenetic Determinants for Optimizing the Treatment of Chronic Low Back Pain

Recruiting now1 site

The goal of this observational study is to better understand the role of the brain in chronic low back pain patients.

Neuroimmune Responses to Exercise in Chronic Back Pain

Recruiting now1 site

The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain. The study will examine whether a 12-week online exercise program changes these measures compared …

Dex & Mastectomy Pain

Recruiting nowPhase 41 site

Chronic post-surgical pain is a common complication following mastectomy and represents a significant source of long-term morbidity. Pain that persists beyond the expected period of tissue healing can interfere with physical functioning, ps…

Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Recruiting nowPhase 21 site

Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. The purpose of this study is to assess the f…

Alberta Chiropractic SelfBack Study

Recruiting now1 site

Recurrent and persistent low back pain (LBP) is a massive problem in Canada that causes a substantial pain, disability, cost, and even premature death. The good news is that treatments for recurrent and persistent LBP are available. Many g…

Advancing Online Psychology Tools for Chronic Pain

Opening soon1 site

Chronic pain affects more than 20% of Canadians and is associated with significant impacts on physical function, mental health, and quality of life. Despite efforts to improve access to multidisciplinary pain care through centralized referr…

The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study

Opening soon1 site

The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic non-cancer spinal p…

Reducing Opioid Use for Chronic Pain Patients Following Surgery

Recruiting now1 site

Patients with chronic pain are often prescribed long-term opioid therapy, despite the serious risks and growing concerns related to opioid use. The Toronto General Hospital has created the world's first multidisciplinary perioperative Trans…

Emotion and Memory in Chronic Neuropathic Pain

Recruiting now1 site

Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain. Abnormalities in brain structures associated with emoti…

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