Osteoarthritis clinical trials recruiting in Canada

Stopping OsteoARthritis After an ACL Tear

Recruiting now2 sites

By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will develop oste…

FitJoints: Getting Fit for Hip and Knee Replacement

Recruiting now4 sites

Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis. The number of people waiting for elective surgeries has spiked in …

Cannabinoids for Osteoarthritis Pain Effectiveness Trial

Recruiting now3 sites

This study aims to investigate whether oral cannabis extracts can effectively manage pain caused by osteoarthritis (OA), a common joint condition affecting one in seven Canadians. Current OA treatments often have limited effectiveness and m…

Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis

Recruiting now3 sites

People with knee arthritis often experience constant pain, and current treatments aren't very effective. This can lead to limited movement and more health problems. Knee arthritis is a big part of healthcare costs in Canada, and its pain is…

The Effect of a Group Exercise Intervention on Balance in People With Knee Osteoarthritis: a Pilot Study

Recruiting now2 sites

In this study, the investigators want to find out if a 12-week exercise program improves balance in people with knee osteoarthritis. This study will involve two visits to the School of Kinesiology at the University of the Fraser Valley (Ch…

Stem Cell Study in Osteoarthritis of the Knee and Hip Joints

Recruiting nowPhase 21 site

The purpose of this trial is to compare the effect of a single intra-articular injection of Lipoaspirate Concentrate vs Bone Marrow Aspirate on pain reduction and functional improvement in the treatment of the knee and hip OA.

The Combined Use of PRP with Lipoaspirate And/or Bone Marrow Aspirate in Osteoarthritis

Recruiting nowPhase 21 site

To demonstrate the efficacy of the combined use of platelet-rich plasma (PRP) with lipoaspirate and/or bone marrow aspirate in osteoarthritis of major joints, and to compare the outcomes achieved using three combinations: PRP plus lipoaspir…

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

Recruiting nowPhase 22 sites

Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typi…

Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)

Recruiting now1 site

People who live in rural areas and have hip or knee arthritis can have difficulty receiving physical therapy (PT) close to home. Living with hip or knee arthritis can make doing daily activities and being physically active difficult. This c…

The WHERE Study: Waiting for Hip and KneE REplacement

Recruiting now1 site

Total hip and knee replacements (TJR) for osteoarthritis are common orthopaedic procedures performed in Canada. Waits for these procedures are already common and lengthy, and the COVID-19 pandemic has resulted in the further of delay of tho…

Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

Recruiting nowPhase 2/32 sites

ABLE OA is a Health Canada authorized (phase II/III) trial \[Parent Control #: 263591\]. A multi-center, prospective, double-blinded, randomized, placebo-controlled adaptive trial to evaluate the efficacy of two minimally manipulated autolo…

Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)

Recruiting nowPhase 42 sites

Knee replacement surgery for osteoarthritis is a commonly performed procedure in Canada with 75,000 of these surgeries performed each year. Success rate for knee replacement surgery is high but more than 20% of patients are still dissatisfi…

A Multi-centre Study of Shoe-worn Insoles and Knee Osteoarthritis

Recruiting now1 site

Shoe-worn insoles (also known as orthotics) can provide symptomatic relief for people with knee osteoarthritis. However, given they act at the feet, and given that many people with knee osteoarthritis also report foot pain, it is important …

Genicular Artery Embolization vs Nerve Ablation Intervention (GENI) for Knee Osteoarthritis

Recruiting now1 site

The genicular artery embolization vs nerve ablation intervention (GENI) knee OA study is a three-arm randomized controlled trial to evaluate symptoms of knee osteoarthritis (OA) in patients after receiving one of three interventions: sham p…

Evaluating XPERIENCE™ Advanced Surgical Irrigation

Recruiting now8 sites

A prospective, multi-center, double-arm, parallel, interventional, randomized, controlled clinical trial to assess the rate of periprosthetic joint infection (PJI) in patients undergoing primary total knee arthroplasty (TKA), total hip arth…

The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty

Recruiting now1 site

Osteoarthritis (OA) is the most common joint disease, causing severe pain due to joint inflammation (synovitis). While total knee arthroplasty (TKA) is commonly performed to reduce pain, 20% of patients are dissatisfied with their outcome p…

Changes in Postural Stability Following THA for OA

Recruiting now1 site

Total hip arthroplasty (THA) is a common surgery that eases pain, restores functional movement, and improves the overall quality of life in people with severe hip osteoarthritis (OA). Unfortunately, problems with postural stability, commonl…

Multiprofen-CC to Reduce Pain in Hand Arthritis

Recruiting nowPhase 31 site

This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The re…

Recombinant Human Growth Hormone (rHGH) for Knee Osteoarthritis (KORR)

Recruiting nowPhase 1/21 site

The goal of this clinical trial is to see if people with knee osteoarthritis would be willing to comply and adhere to incorporating Recombinant Human Growth Hormone (rHGH), specifically Saizen Somatropin solution, into their treatment plan.…

Using ROSA for Challenging The TKA Standard of Care

Recruiting nowPhase 41 site

This is a prospective, randomized controlled trial using the cruciate retaining, MC Persona to comparing the conventional TKA to ROSA assisted TKA. Patients will be randomized to one of three study trial arms. 1. Standard of care medial pa…

Emphasys Radiostereometric Analysis

Recruiting now1 site

This study is designed as a prospective, multi-centre, non-randomized, non-controlled study. This study does not limit the procedures involved in the treatment of the subject as long as the protocol specified products are utilized. The pri…

TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion

Recruiting now1 site

This study will compare total shoulder arthroplasty (TSA) with an augmented glenoid component and reverse shoulder arthroplasty (RSA) procedures, in participants with advanced glenohumeral osteoarthritis aged 65 years and older, who also pr…

Testing of a New Joint Protection Program

Opening soon1 site

The goal of this study is to to examine the feasibility of a full-scale trial on Helping Hand, a new Joint Protection Program for Hand Osteoarthritis and to examine the acceptability of the new Joint Protection Program. This study will not…

Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses

Recruiting now1 site

The purpose of the study is to determine if knee replacement performed using Journey II implant is different from two other standard-of-care knee replacements using Stryker and Zimmer in terms of knee movements and forces, walking patterns,…

TSA Techniques in Glenohumeral OA

Recruiting now1 site

Osteoarthritis (OA) of the shoulder is a disease resulting from the wearing down of cartilage over time. OA can produce pain and dysfunction at the affected joint and is a growing occurrence in an aging population. Total shoulder arthroplas…

TSA vs RSA in Glenohumeral Osteoarthritis

Recruiting now4 sites

This study will compare total shoulder arthroplasty (TSA) reverse shoulder arthroplasty (RSA) procedures, in the context of a prospective, randomized-controlled trial to determine the optimal treatment in patients 65 years of age and older,…

Comparison of the Analgesic Effect of 2 Shoulder Infiltrations

Recruiting now1 site

For patients suffering of osteoarthritis, only analgesic treatments such as anti-inflammatory drugs and cortisone infiltrations provide significant but temporary relief of their pain. The objective is to compare the analgesic effect of 2 in…

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Recruiting nowPhase 395 sites

The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. …

Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis

Opening soonPhase 31 site

The purpose of the ACCELERATE3 trial is to assess the efficacy of a single intra-articular (IA) injection of autologous BMAC, in one or both knees, compared to a single IA injection of Standard of Care (SOC) in patients with mild to severe …

Hip Replacement System (HRS-P) in Primary Total Hip Arthroplasty

Recruiting now1 site

To evaluate effectiveness and safety of HHRS in subjects undergoing total hip arthroplasty (THA). Effectiveness will be evaluated using patient-reported, clinical, radiologic, and radiostereometric outcomes. Safety will be evaluated through…

Common questions

How do I find a osteoarthritis clinical trial near me in Canada?

Use Beacon's free search: enter "osteoarthritis", your age, and your location, and you'll see recruiting trials sorted by distance, each explained in plain language — including sites just across the US border. Beacon searches the full official registry and never requires an account.

Does joining a clinical trial cost money?

The study treatment and study-related tests are usually provided at no cost, and some trials help with travel. In Canada, your provincial health coverage continues to apply to your routine care — always confirm details with the study team.

Can I leave a clinical trial after joining?

Yes. Participation is always voluntary, and you can leave a trial at any time, for any reason, without losing your normal medical care.

Do I qualify for these trials?

Every trial has its own eligibility criteria. Beacon translates each trial's criteria into a plain-language checklist you can review and bring to your doctor — only the study team can confirm whether you qualify.